Is oxidative stress induced by mRNA vaccination (Pfizer, Moderna) also responsible for telomere shortening?
The spike protein of vaccines induces also inflammation and oxidative stress by binding to ACE2 receptors throughout the body (Lesgards JF, 2021).
Given the severity of the observed side effects and the fact that the biochemical mechanisms are partly similar, it can be hypothesized that mRNA vaccines can oxidize guanines from DNA and partly telomeres. It is known that post-vaccine inflammation is produced and sought to amplify the immune response and the production of antibodies, and if we add to it the inflammatory and pro-oxidant action (one does not go without the other), induced by the spike protein and which can last for at least 15 days (Ogata AF et al., 2021), there is a very favorable environment for the oxidation of DNA bases, the most fragile of which is guanine, especially on telomeres.
In fact, one study showed that vaccination with the Pfizer vaccine led to an increase in oxidative stress levels (assessed by glutathione measurement) that returned to normal after 14 days (Ntouros PA et al., 2021). This period is nevertheless sufficient to induce damage to the telomeres.
This oxidative stress produced by vaccination also poses another problem which is the stability of the mRNA of the vaccines itself! Surprisingly, the mRNAs of the Pfizer and Moderna vaccines have been enriched with guanines! This is supposed to increase the translation of RNA into spike protein: indeed, if we study the nucleotide sequence of the SARS-CoV2 virus spike gene, and compare it to the sequence encoding the spike protein of the vaccine, we notice many differences that, however, do not affect the product of the translation (because they are synonymous codons). These nucleotide sequence modifications were introduced by the researchers for greater vaccine efficacy (they replaced bases with G's, as much as possible, to increase translation efficiency).
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But in the same way that it is impossible for manufacturers to ignore the toxicity of the spike protein known for ten years, it is even more impossible to ignore the fragility (oxidibility) of guanines!
It is therefore surprising that none of the regulatory authorities in charge of evaluating the marketing authorisation applications for these vaccines (FDA and EMA in particular), knowing the sensitivity of telomeres and DNA to oxidative stress, have requested a toxicity study on genes (genotoxicity).
Excerpt from the EMA report on Comirnaty (Pfizer vaccine): " Genotoxicity: No genotoxicity studies were provided. This is acceptable because the components present in the vaccine formulation are lipids and RNA that are not expected to have genotoxic potential (EMA, 2021) ».
From a scientific point of view and in terms of safety, this can be considered irresponsible.
Are the spike proteins in RNA vaccines more harmful than the spike protein in the SARS-CoV2 virus?
The following three experimental and theoretical explanations make it possible to answer in the affirmative. The "apprentice life technologists" thought to make the RNA of vaccines more stable by doping it into G bases, without modifying the corresponding amino acids, something allowed thanks to the "mode of operation" of the universal genetic code that allows several triplets of distinct codons to code for a single amino acid. Unfortunately, this leads in the context of vaccine RNAs to a diametrically opposite result since they become more unstable, more fragile and more brittle.
1 - The article "vaccine-induced Covid-19 mimicry" syndrome (Marschalek et al., 2021) shows how this G-based doping of spike RNA can cause changes in the reading frame of the codons, thus partial sequences of different amino acids, which can ultimately lead to thromboembolic events in patients immunized by covid-19 vaccines.
2 - In addition, it has been demonstrated how this excess of G bases of the RNA of the vaccine spike reduces to zero the megastructures according to UA/ CG proportions defined by Fibonacci while on the contrary, the spike of the virus and especially that of the variants sees the complexity and quantity of such structures enriched. To put it simply, this means that vaccine RNA is just one stacking of nucleotides without the slightest spine ensuring a megastructure at medium and long distances, while variants acquire from day to day a greater solidity and overall cohesion of their RNA. (Perez JC 2021)
3 - This inconsistency can also be visualized in the figure below as a kind of "fractal roughness" which is much more unstable and inharmonious in vaccine spike RNA (Pfizer in particular) than in the RNA of the spike of the virus. This was shown using the master code.