Syria's state news agency SANA said four U.S. helicopters crossed the border and struck a farm about 8 kilometers (5 miles) inside Syria before returning to Iraqi airspace.
The raid occurred about 4:45 p.m. (1345 GMT). The helicopters hit a civilian building under construction on the farm, killing killing three men, the wife of a guard and four children, SANA said.
Military officials are investigating the claims, Sgt. Brooke Murphy, a U.S. military spokeswoman, told CNN.
"Unfortunately, we cannot confirm anything at the moment," she said.
The attack occurred near the town of Al-Bukamal, which is home to a Red Crescent camp for Iraqi refugees.
The town is across the border from the Iraqi city of Qaim, which has been a major route for Sunni Arab fighters battling U.S. troops in Iraq.
Syria demanded Iraq's government "immediately investigate this serious violation" and bar U.S. forces from striking Syria from its territory. The Syrian government summoned U.S. and Iraqi diplomats to the Foreign Ministry in Damascus to condemn the attack, SANA reported
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