1 aspirin na dan

[aleckovic]

Da li ima smisla piti svaki dan po 1 aspirin - i od koje godine poceti ?

Najnovije studije pokazuju da je dobar i protiv kancera: http://www.medicalnewstoday.com/articles/248937.php

Ima li tko ko se razumje u medicinu ?

[plagijator1975]

Ja pijem Aspirin protect 100 svaki dan već 2-3 mjeseca, čuo sam da je to dobro. Kažu da se pije iznad 40 godine, mada ja imam 37.

Sent from my GT-I9100 using Tapatalk 2

[shiny]

Šansa da će ti prevenirati cancer je 1%, a da će ti uništiti želudac i izazvati krvarenja 90% ...

[aleckovic]

Šansa da će ti prevenirati cancer je 1%, a da će ti uništiti želudac i izazvati krvarenja 90% ...

Doktor si ?

Da li tko zna sa sigurnoscu ?

ne mislim samo na kancer, mislim i na zastitu od srcanog/mozdanog udara...

[GaRGa]

godisnje na svijetu umre oko 8000 osoba od aspirina...

Adverse effects

[edit]Contraindications
Aspirin should not be taken by people who are allergic to ibuprofen or naproxen,[75][76] or who have salicylate intolerance[77][78] or a more generalized drug intolerance to NSAIDs, and caution should be exercised in those with asthma or NSAID-precipitated bronchospasm. Owing to its effect on the stomach lining, manufacturers recommend people with peptic ulcers, mild diabetes, or gastritis seek medical advice before using aspirin.[75][79] Even if none of these conditions is present, the risk of stomach bleeding is still increased when aspirin is taken with alcohol or warfarin.[75][76] Patients with hemophilia or other bleeding tendencies should not take aspirin or other salicylates.[75][79] Aspirin is known to cause hemolytic anemia in people who have the genetic disease glucose-6-phosphate dehydrogenase deficiency, particularly in large doses and depending on the severity of the disease.[80] Use of aspirin during dengue fever is not recommended owing to increased bleeding tendency.[81] People with kidney disease, hyperuricemia, or gout should not take aspirin because it inhibits the kidneys' ability to excrete uric acid, and thus may exacerbate these conditions. Aspirin should not be given to children or adolescents to control cold or influenza symptoms, as this has been linked with Reye's syndrome.[11]
[edit]Gastrointestinal
Aspirin use has been shown to increase the risk of gastrointestinal bleeding.[82] Although some enteric-coated formulations of aspirin are advertised as being "gentle to the stomach", in one study, enteric coating did not seem to reduce this risk.[82] Combining aspirin with other NSAIDs has also been shown to further increase this risk.[82] Using aspirin in combination with clopidogrel or warfarin also increases the risk of upper gastrointestinal bleeding.[83]
In addition to enteric coating, "buffering" is the other main method companies have used to try to mitigate the problem of gastrointestinal bleeding. Buffering agents are intended to work by preventing the aspirin from concentrating in the walls of the stomach, although the benefits of buffered aspirin are disputed. Almost any buffering agent used in antacids can be used; Bufferin, for example, uses MgO. Other preparations use CaCO3.[84]
Taking it with vitamin C is a more recently investigated method of protecting the stomach lining. Taking equal doses of vitamin C and aspirin decreases the amount of stomach damage that occurs compared to taking aspirin alone.[85][86]
[Deglycyrrhizinated licorice]] (DGL), an extract of the popular herb licorice, has been reported to help relieve the symptoms of gastritis. In a 1979 research study, a dose of 350 mg DGL was shown to decrease the amount of gastrointestinal bleeding induced by three adult-strength aspirin tablets (750 mg).[87]
A dose of 500 mg of S-adenosyl-methionine (SAMe, an amino acid naturally formed in the body) given together with a large dose of aspirin (1300 mg) reduced the amount of stomach damage by 90%.[88]
In contrast to oral aspirin, intravenous injection of aspirin did not produce detectable histological damage or significantly alter gastric mucosal potential difference, and high blood levels of circulating salicylate did not acutely damage gastric mucosa, so the gastric mucosal damage produced acutely after single oral doses of aspirin are due to its topical, rather than systemic, action.[89]
[edit]Anemia
High-dose, long-term use of aspirin can cause iron deficiency anemia.[90]
[edit]Central effects
Large doses of salicylate, a metabolite of aspirin, have been proposed to cause tinnitus (ringing in the ears) based on experiments in rats, via the action on arachidonic acid and NMDA receptors cascade.[91]
[edit]Reye's syndrome
Main article: Reye's syndrome
Reye's syndrome, a rare but severe illness characterized by acute encephalopathy and fatty liver, can occur when children or adolescents are given aspirin for a fever or other illnesses or infections. From 1981 through 1997, 1207 cases of Reye's syndrome in under-18 patients were reported to the US Centers for Disease Control and Prevention. Of these, 93% reported being ill in the three weeks preceding onset of Reye's syndrome, most commonly with a respiratory infection, chickenpox, or diarrhea. Salicylates were detectable in 81.9% of children for whom test results were reported.[92] After the association between Reye's syndrome and aspirin was reported, and safety measures to prevent it (including a Surgeon General's warning, and changes to the labeling of aspirin-containing drugs) were implemented, aspirin taken by children declined considerably in the United States, as did the number of reported cases of Reye's syndrome; a similar decline was found in the United Kingdom after warnings against pediatric aspirin use were issued.[92] The US Food and Drug Administration now recommends aspirin (or aspirin-containing products) should not be given to anyone under the age of 12 who has a fever,[11] and the British Medicines and Healthcare products Regulatory Agency recommends children who are under 16 years of age should not take aspirin, unless it is on the advice of a doctor.[93]
[edit]Hives and swelling
For a small number of people, taking aspirin can result in symptoms resembling an allergic reaction, including hives, swelling and headache. The reaction is caused by salicylate intolerance and is not a true allergy, but rather an inability to metabolize even small amounts of aspirin, resulting in an overdose.
[edit]Other effects
Aspirin can induce angioedema (swelling of skin tissues) in some people. In one study, angioedema appeared one to six hours after ingesting aspirin in some of the patients. However, when the aspirin was taken alone, it did not cause angioedema in these patients; the aspirin had been taken in combination with another NSAID-induced drug when angioedema appeared.[94]
Aspirin causes an increased risk of cerebral microbleeds having the appearance on MRI scans of 5- to 10-mm or smaller, hypointense (dark holes) patches.[95][96] Such cerebral microbleeds are important, since they often occur prior to ischemic stroke or intracerebral hemorrhage, Binswanger disease and Alzheimer's disease.[original research?]
A study of a group with a mean dosage of aspirin of 270 mg per day estimated an average absolute risk increase in intracerebral hemorrhage (ICH) of 12 events per 10,000 persons.[97] In comparison, the estimated absolute risk reduction in myocardial infarction was 137 events per 10,000 persons, and a reduction of 39 events per 10,000 persons in ischemic stroke.[97] In cases where ICH already has occurred, aspirin use results in higher mortality, with a dose of approximately 250 mg per day resulting in a relative risk of death within three months after the ICH of approximately 2.5 (95% confidence interval 1.3 to 4.6).[98]
Aspirin and other NSAIDs can cause hyperkalemia by inducing a hyporenin hypoaldosteronic state via inhibition of prostaglandin synthesis; however, these agents do not typically cause hyperkalemia by themselves in the setting of normal renal function and euvolemic state.[99]
Aspirin can cause prolonged bleeding after operations for up to 10 days. In one study, 30 of 6499 elective surgical patients required reoperations to control bleeding. Twenty had diffuse bleeding and 10 had bleeding from a site. Diffuse, but not discrete, bleeding was associated with the preoperative use of aspirin alone or in combination with other NSAIDS in 19 of the 20 diffuse bleeding patients.[100]

[GaRGa]

[talić]

za farmaceutsku industriju je sigurno dobro.

[butterfly_01]

meni je izazvao krvarenje.. ne planiram ga nikad poceti piti.

[otherside]

aspirin se kao i svaki drugi lijek uzima po preporuci ljekara tj.mora postojati razlog zbog koga se on uvodi u terapiju.
nije to vitamin, mineral ili neki dijetetski proizvod pa da se koristi na svoju ruku.
sem toga, aspirin mijenja viskozitet krvi sto utice na koagulaciju i stvaranje tromba. samim tim, naglo prekidanje uzimanja moze dovesti do povecanog rizika nastanka tromboze.
ja ga bez razloga sigurno ne bih uzimala...
cak i ta jacina od 100 mg tzv. protektivna za kardiovaskularna i cerebrovaskularna oboljenja je diskutabilna jer novije studije pokazuju da 75 mg ili 50 mg aspirina ima zadovoljavajuci terapijski ucinak a manje nezeljenih efekata.

[talić]

aspirin se kao i svaki drugi lijek uzima po preporuci ljekara tj.mora postojati razlog zbog koga se on uvodi u terapiju.
nije to vitamin, mineral ili neki dijetetski proizvod pa da se koristi na svoju ruku.
sem toga, aspirin mijenja viskozitet krvi sto utice na koagulaciju i stvaranje tromba. samim tim, naglo prekidanje uzimanja moze dovesti do povecanog rizika nastanka tromboze.
ja ga bez razloga sigurno ne bih uzimala...
cak i ta jacina od 100 mg tzv. protektivna za kardiovaskularna i cerebrovaskularna oboljenja je diskutabilna jer novije studije pokazuju da 75 mg ili 50 mg aspirina ima zadovoljavajuci terapijski ucinak a manje nezeljenih efekata.

dobro zboriš. Meni jedan dobar doktor reče da je 40 mg dovoljno. Tema razgovora je bio moj otac koji je imao infarkt. Dakle samo kao preventiva novog infarkta ili moždanog kod starijih osoba koje ga podnose.

[graue_maus]

cula sam da reumaticari ne smiju ni po koju cijenu uzimati aspirin jer im se simptomi pogorsaju ...zna li neko vise o tome ..

[otherside]

cula sam da reumaticari ne smiju ni po koju cijenu uzimati aspirin jer im se simptomi pogorsaju ...zna li neko vise o tome ..

ako mislis na reumatoidni atritis ne bih rekla da je to tacno.
aspirin ne bi trebao pogorsati simptome ali danas postoje efikasniji lijekovi od aspirina pa se njegova uloga u lijecenju RA jednostavno reducirala.

[silm]

godisnje na svijetu umre oko 8000 osoba od aspirina...

Adverse effects

[edit]Contraindications
Aspirin should not be taken by people who are allergic to ibuprofen or naproxen,[75][76] or who have salicylate intolerance[77][78] or a more generalized drug intolerance to NSAIDs, and caution should be exercised in those with asthma or NSAID-precipitated bronchospasm. Owing to its effect on the stomach lining, manufacturers recommend people with peptic ulcers, mild diabetes, or gastritis seek medical advice before using aspirin.[75][79] Even if none of these conditions is present, the risk of stomach bleeding is still increased when aspirin is taken with alcohol or warfarin.[75][76] Patients with hemophilia or other bleeding tendencies should not take aspirin or other salicylates.[75][79] Aspirin is known to cause hemolytic anemia in people who have the genetic disease glucose-6-phosphate dehydrogenase deficiency, particularly in large doses and depending on the severity of the disease.[80] Use of aspirin during dengue fever is not recommended owing to increased bleeding tendency.[81] People with kidney disease, hyperuricemia, or gout should not take aspirin because it inhibits the kidneys' ability to excrete uric acid, and thus may exacerbate these conditions. Aspirin should not be given to children or adolescents to control cold or influenza symptoms, as this has been linked with Reye's syndrome.[11]
[edit]Gastrointestinal
Aspirin use has been shown to increase the risk of gastrointestinal bleeding.[82] Although some enteric-coated formulations of aspirin are advertised as being "gentle to the stomach", in one study, enteric coating did not seem to reduce this risk.[82] Combining aspirin with other NSAIDs has also been shown to further increase this risk.[82] Using aspirin in combination with clopidogrel or warfarin also increases the risk of upper gastrointestinal bleeding.[83]
In addition to enteric coating, "buffering" is the other main method companies have used to try to mitigate the problem of gastrointestinal bleeding. Buffering agents are intended to work by preventing the aspirin from concentrating in the walls of the stomach, although the benefits of buffered aspirin are disputed. Almost any buffering agent used in antacids can be used; Bufferin, for example, uses MgO. Other preparations use CaCO3.[84]
Taking it with vitamin C is a more recently investigated method of protecting the stomach lining. Taking equal doses of vitamin C and aspirin decreases the amount of stomach damage that occurs compared to taking aspirin alone.[85][86]
[Deglycyrrhizinated licorice]] (DGL), an extract of the popular herb licorice, has been reported to help relieve the symptoms of gastritis. In a 1979 research study, a dose of 350 mg DGL was shown to decrease the amount of gastrointestinal bleeding induced by three adult-strength aspirin tablets (750 mg).[87]
A dose of 500 mg of S-adenosyl-methionine (SAMe, an amino acid naturally formed in the body) given together with a large dose of aspirin (1300 mg) reduced the amount of stomach damage by 90%.[88]
In contrast to oral aspirin, intravenous injection of aspirin did not produce detectable histological damage or significantly alter gastric mucosal potential difference, and high blood levels of circulating salicylate did not acutely damage gastric mucosa, so the gastric mucosal damage produced acutely after single oral doses of aspirin are due to its topical, rather than systemic, action.[89]
[edit]Anemia
High-dose, long-term use of aspirin can cause iron deficiency anemia.[90]
[edit]Central effects
Large doses of salicylate, a metabolite of aspirin, have been proposed to cause tinnitus (ringing in the ears) based on experiments in rats, via the action on arachidonic acid and NMDA receptors cascade.[91]
[edit]Reye's syndrome
Main article: Reye's syndrome
Reye's syndrome, a rare but severe illness characterized by acute encephalopathy and fatty liver, can occur when children or adolescents are given aspirin for a fever or other illnesses or infections. From 1981 through 1997, 1207 cases of Reye's syndrome in under-18 patients were reported to the US Centers for Disease Control and Prevention. Of these, 93% reported being ill in the three weeks preceding onset of Reye's syndrome, most commonly with a respiratory infection, chickenpox, or diarrhea. Salicylates were detectable in 81.9% of children for whom test results were reported.[92] After the association between Reye's syndrome and aspirin was reported, and safety measures to prevent it (including a Surgeon General's warning, and changes to the labeling of aspirin-containing drugs) were implemented, aspirin taken by children declined considerably in the United States, as did the number of reported cases of Reye's syndrome; a similar decline was found in the United Kingdom after warnings against pediatric aspirin use were issued.[92] The US Food and Drug Administration now recommends aspirin (or aspirin-containing products) should not be given to anyone under the age of 12 who has a fever,[11] and the British Medicines and Healthcare products Regulatory Agency recommends children who are under 16 years of age should not take aspirin, unless it is on the advice of a doctor.[93]
[edit]Hives and swelling
For a small number of people, taking aspirin can result in symptoms resembling an allergic reaction, including hives, swelling and headache. The reaction is caused by salicylate intolerance and is not a true allergy, but rather an inability to metabolize even small amounts of aspirin, resulting in an overdose.
[edit]Other effects
Aspirin can induce angioedema (swelling of skin tissues) in some people. In one study, angioedema appeared one to six hours after ingesting aspirin in some of the patients. However, when the aspirin was taken alone, it did not cause angioedema in these patients; the aspirin had been taken in combination with another NSAID-induced drug when angioedema appeared.[94]
Aspirin causes an increased risk of cerebral microbleeds having the appearance on MRI scans of 5- to 10-mm or smaller, hypointense (dark holes) patches.[95][96] Such cerebral microbleeds are important, since they often occur prior to ischemic stroke or intracerebral hemorrhage, Binswanger disease and Alzheimer's disease.[original research?]
A study of a group with a mean dosage of aspirin of 270 mg per day estimated an average absolute risk increase in intracerebral hemorrhage (ICH) of 12 events per 10,000 persons.[97] In comparison, the estimated absolute risk reduction in myocardial infarction was 137 events per 10,000 persons, and a reduction of 39 events per 10,000 persons in ischemic stroke.[97] In cases where ICH already has occurred, aspirin use results in higher mortality, with a dose of approximately 250 mg per day resulting in a relative risk of death within three months after the ICH of approximately 2.5 (95% confidence interval 1.3 to 4.6).[98]
Aspirin and other NSAIDs can cause hyperkalemia by inducing a hyporenin hypoaldosteronic state via inhibition of prostaglandin synthesis; however, these agents do not typically cause hyperkalemia by themselves in the setting of normal renal function and euvolemic state.[99]
Aspirin can cause prolonged bleeding after operations for up to 10 days. In one study, 30 of 6499 elective surgical patients required reoperations to control bleeding. Twenty had diffuse bleeding and 10 had bleeding from a site. Diffuse, but not discrete, bleeding was associated with the preoperative use of aspirin alone or in combination with other NSAIDS in 19 of the 20 diffuse bleeding patients.[100]

Ma sve sam te razumio , ne moras vise kucati ovako pametno! Sjedi dole petica!

[pussysmoke]

.

[aleckovic]

Najnovija studija pokazuje da se koristi 162 mg aspirina dnevno, isto zagovara i dr. Solakovic



"I vi tvrdite da Aspirin 100 ima bajkovite učinke kao preventiva od srčanih oboljenja?

- Muškarci poslije 35, a žene poslije 45 godine života trebaju da piju Aspirin od 162 miligrama. Kod nas u prodaji ne možete naći Aspirin od 162 miligrama, već samo od 100. Ali uzmete jednu tabletu i prepolovite je i dobijete potrebnu dozu. To pakovanje se proizvodi u SAD, jer oni prodaju Aspirin od 81 miligram i pije se jedna tableta ujutru i jedna navečer.


Jedan farmaceut mi je preporučio da Aspirin pijem navečer, a ne ujutro. Kazao mi je da se najviše srčanih udara događa od dva do četiri sata ujutro, jer tako su im rekli stručnjaci na seminaru. Zašto vi tvrdite drugačije?


- O tome i pričam cijelo vrijeme. Mi slušamo neke farmaceute, nadriljekare, a ne gledamo šta je nauka o tome rekla. Amerikanci su napravili sutudiju na hiljadama pacijenata i naučno dokazali na koji način se treba uzimati Aspirin. Dakle, ja preporučujem samo ono što je naučno dokazano.


Problem je u tome što naše Ministarstvo zdravlja ne informiše ljude o naučnim dostignućima. Vlada nema programa i samo se bave nekim donacijama, a ne brinu se o prevenciji zdravlja svoga naroda. O tome se treba učiniti u obdaništima, osnovnim školama, fakultetima i država je dužna da sve to organizuje!"

p.s.
Ne obracajte paznju na ove likove sa crtezom marihuane, to su narkomani, a ovaj jedan od njih u kuci uzgaja marihuanu, tvrde da je ista zdravija od spinata, a od nje se nikad niko ne moze razboliti niti umrijeti - svi su psihicki ovisnici o marihuani, imaju svoj post na forumu. Isti smatraju da farmaceuti i doktori ubijaju i ne daju da se marihuana prodaje na svim mjestima, jer bi izlijecila sve ljude na svijetu

[pussysmoke]

.

[talić]

taj doktor Solaković je da ne kažem komad čega. Nauka još uvijek nije dokazala ni da li je čaša vode više nego što piješ zdrava ili štetna a o aspirinu da i ne govorimo.
Ko garantuje da uzimanje aspirina neće izazvati pokretanje nekog stabilnog tromba koji će izazvati infarkt ili moždani i ubiti čovjeka.

[aleckovic]

taj doktor Solaković je da ne kažem komad čega. Nauka još uvijek nije dokazala ni da li je čaša vode više nego što piješ zdrava ili štetna a o aspirinu da i ne govorimo.
Ko garantuje da uzimanje aspirina neće izazvati pokretanje nekog stabilnog tromba koji će izazvati infarkt ili moždani i ubiti čovjeka.

Sve znam, zato je i pokrenuta tema...

[Lacrosse]

Garantuje nauke svugdje.

Evo Americkih guidelines...
Dakle muskarci preko 45 godina treba da piju baby aspirin, doza 75-81-100mg, nije bitno.
Zene preko 55 godina takodje trebaju da piju.
Kod muskaraca aspirin smanjuje sansu za infarktom miokarda, kod zena sansu za iskemijski infarkt mozga.
Preporuka je do 80 godina.
Preko 80 godina, sto se tice primarne prevencije, ne postoji preporuka, dakle za nekog koje nije imao srcani/mozdani udar nikada.

Evo i web stranica zurnala porodicne medicine:

Summary of Recommendations and Evidence
The U.S. Preventive Services Task Force (USPSTF) recommends the use of aspirin in men 45 to 79 years of age when the potential benefit of a reduction in myocardial infarctions (MIs) outweighs the potential harm of an increase in gastrointestinal (GI) hemorrhage. A recommendation.

The USPSTF recommends the use of aspirin in women 55 to 79 years of age when the potential benefit of a reduction in ischemic strokes outweighs the potential harm of an increase in GI hemorrhage. A recommendation.

The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of aspirin for cardiovascular disease (CVD) prevention in men and women 80 years and older. I statement.

The USPSTF recommends against the use of aspirin for stroke prevention in women younger than 55 years and for MI prevention in men younger than 45 years. D recommendation.

Grade A recommendation = nekoliko studija s najvecim nivom (RCT - randomized controlled trials).

Ovo normalno ne ukljucuje ljude koji su imali cireve na zeludcima i prethodno gastrointestinalno krvarenje.

Na drugu ruku, vecina Aspirina koji se prodaje danas dolazi u EC = entericaly coated capsules. To su posebne pilule koje dodatno osiguravaju prevenciju stomacnih ulcera pri koristenju aspirina. Takodje smanjuju osjecaj zgaravice kod koristenja aspirina, sto je jedna od najcescih prigovora koje pacijenti imaju.

I na kraju, vecina cireva koji su uzrokovani NSAIDs, i sami zarastu, s nekim od proton pump inhibitor ljekova (omeprazole/pantaprazole, etc). Dok, recimo infarkti miokarda i mozdani udari nece se nikad podmladiti. Isto tako, pogledati treba gdje je krvarenje iz gastointestinalnog trakta na ljestvici po pitanju mortaliteta, a gdje su srcani i mozdani udari.

Normalno, ovo je primarna prevencija. Slicno kao i vakcinacija. Nas gro nikad nije bilo izlozeno tuberkulozi, pa bebama i dalje daju BSG vakcinu. Tako je i ovo, hit & miss. Ali, za onog ko o sebi vodi racuna, aspirin je uvijek dobra stvar. Normalno kad se koristi treba izbjegavati koristenje drugih NSAID's za bolove, vec koristiti striktno paracetamol/Tylol. Diklofenaci, Ibuprofeni, itd se nebi trebali koristiti istovremeno, u velikim dozama. Takodje i steroidi, kao prednison, se nebi trebali uzimati zajedno bez nekog ljeka koji supresira stomacnu kiselinu. I treba voditi racuna da ti stolica ne promjeni boju u crnu. Ako ti stolica pocrni to znaci da krvaris negdje, ukoliko nisi na suplementima sa zeljezom. Tako da svaki dan moze se pokazati i dokazati da li krvaris ili ne.

Vecina kronicnih srcanih bolesnika je na tkz. troduploj antikoagulacionoj terapiji - Aspirini, Plavix ili Clopidogrel, i Warfarin ili Kumarin, kad udruzis ovakva tri ljeka zajedno, to je nesto sasvim drukcije od baby aspirina svaki dan.
Sto se tice efekta Aspirina na kolorektalne rakove, ne postoje nikakve generalne preporuke, iako u zadnje vrijeme je bilo nekoliko studija koje su sve zakljucile da koristenje aspirina je umanjilo broj onih s rakom, od 16-40%. Ovo se odnosi samo na Gastrointestinalne rakove.

[talić]

@Lacrosse,

ko plaća sve te studije koje govore o učinkovitosti lijekova ?
Iste farmaceutske kuće koje ih i prodaju.
Čak i one koje plati neko drugi ne isključuje subjektivno mišljenje ( mito i korupcija).
Evo spominješ i paracetamol.
Još jedan od lijekova koje treba izbjegavati jer se javljaju sve češći slučajevi zatajenja jetre zbog paracetamola čak i kod dnevnih doza koje su tek 2 do 3 puta preko dozvoljene.
Oranizmi na planeti postoje par milijardi godina i cijelo vrijeme (evoluiraju) uče kako da savladaju sve postavljene prepreke.
Mislim da je organizmu daleko korisnije 15 minuta šetnje i par stotina kalorija manje nego aspirin.
S obzirom na povećanje prosječne tjelesne mase čovjeka u posljednjih pedesetak godina organizam se jako dobro snalazi sa novim izazovima što pokazuje i produljenje životnog vijeka ljudi.

[Lacrosse]

@Lacrosse,

ko plaća sve te studije koje dokazuju o učinkovitosti lijekova ?
Iste farmaceutske kuće koje ih i prodaju.
Čak i one koje plati neko drugi ne isključuje subjektivno mišljenje ( mito i korupcija).
Evo spominješ i paracetamol.
Još jedan od lijekova koje treba izbjegavati jer se javljaju sve češći slučajevi zatajenja jetre zbog paracetamola čak i kod dnevnih doza koje su tek 2 do 3 puta preko dozvoljene.
Oranizmi na planeti postoje par milijardi godina i cijelo vrijeme (evoluiraju) uče kako da savladaju sve postavljene prepreke.
Mislim da je organizmu daleko korisnije 15 minuta šetnje i par stotina kalorija manje nego aspirin.
S obzirom na povećanje prosječne tjelesne mase čovjeka u posljednjih pedesetak godina organizam se jako dobro snalazi sa novim izazovima što pokazuje i produljenje životnog vijeka ljudi.

Prijatelju, ja sam ljekar internista. Sta si ti po zanimanju?

Ovo je tema o aspirinu.

Na temu o onima koji ne vjeruju nikakvih istrazivanjima, koji su kontra-establishmenta, i kojima je svaki doktor budala, ti mozes otvoriti i javiti se na nju, zapocni thread.

Ja ovo tebi preporucujem kao ljekar. Nemoj se GRAS--om voziti vec prosetaj. Nemoj se na plin grijati vec izvuci balvane sa Bjelasnice, pa iscjepaj ispred kuce pa uznesi 10 metara drva na 10 sprat, bices zdraviji i bogatiji. Ministar ti je vec rekao, nemoj jesti tri put na dan, vec jedi jednom. Nemoj nikad ko cijeli svijet, vec kontra svijeta. To se zove oppositional defiant personality disorder, i spektrum je oboljena persone iz kluster paranoidnih. To se ne ljeci aspirinom, za to je potrebna jedna jako duga psihoterapija za koju ja nemam volje ni vremena.

Tako imamo zemlju koja je 172 od 173 zemlje u svijetu po izdvajanju u istrazivanje, i imamo one koji diskreditiraju bilo kakvo istrazivanje. Kad je tako brate, kupi kartu za Afganistan i zavuci se tamo ispod kamena, niko te nece nutkati ni aspirinom, ni paracetamolom. Ne mozes ti porediti istrazivanje Bosnaljeka, s istrazivanjem Bayera ili Pfizera. A, niko nikome ne brani da i sam sprovede istrazivanje. Uzmi ti na sebe da okupis sve srcane bolesnike u kantonu Sarajevo, pa neka prestanu uzimati aspirini, s onima koji su na aspirinu. Pa kad umre par ljudi zbog toga, onda mozes objaviti rezultate, da si opet otkrio tocak. Sto se koga cega drugog tice, postoji nauka u medicini koja se zove evidence based medicine. To su istrazivanja koja su objavljenja u zurnalima medicinskim s najstrozim dakle kriterijima, u kojima editori odlucuju od 10,000 istrazivanja kojih 10 je zasluzilo da budu publicirani, a ljudi koji ih obave su potrosili decenije svog rada, ne da bi neka farmaceutska kompanija zaradila 10 maraka na tebi jer kupujes asprin, vec da bi nauka kompletno, otisla korak dalje.

Sto se tice troskova, izracunaj ti koliko kosta njega o covjeku koji je imao mozdani udar 1 dan. Tu pocinjem od terapije do pranja guzice, od pomagala u kuci koja su potrebna, do ljekova, od troskova hospitalizacije, do ne mogucnosti da takva osoba vise ikad radi. Pa pomnozi to sa recimo 5-10 godina koliko ljudi zive poslje mozdanog udara, pa se zapitaj da li bi tebi ljepo bilo da imas najblizu osobu u familiju slogiranu, koliko bi tvoj zivot tebi vrijedio, a koliko njima njihov. Pa kad sve to izracunas, izracunaj onda da je cijeli kanton Sarajevo mogao biti na aspirinu da se sprijeci samo jedna takva tragedija. Ali nije. Zbog mentaliteta u koji ti polazes sve. Ja ne bih bas bio toliko siguran.

[pussysmoke]

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[Sandra N.]

Garantuje nauke svugdje.

Evo Americkih guidelines...
Dakle muskarci preko 45 godina treba da piju baby aspirin, doza 75-81-100mg, nije bitno.
Zene preko 55 godina takodje trebaju da piju.
Kod muskaraca aspirin smanjuje sansu za infarktom miokarda, kod zena sansu za iskemijski infarkt mozga.
Preporuka je do 80 godina.
Preko 80 godina, sto se tice primarne prevencije, ne postoji preporuka, dakle za nekog koje nije imao srcani/mozdani udar nikada.

Evo i web stranica zurnala porodicne medicine:

Summary of Recommendations and Evidence
The U.S. Preventive Services Task Force (USPSTF) recommends the use of aspirin in men 45 to 79 years of age when the potential benefit of a reduction in myocardial infarctions (MIs) outweighs the potential harm of an increase in gastrointestinal (GI) hemorrhage. A recommendation.

The USPSTF recommends the use of aspirin in women 55 to 79 years of age when the potential benefit of a reduction in ischemic strokes outweighs the potential harm of an increase in GI hemorrhage. A recommendation.

The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of aspirin for cardiovascular disease (CVD) prevention in men and women 80 years and older. I statement.

The USPSTF recommends against the use of aspirin for stroke prevention in women younger than 55 years and for MI prevention in men younger than 45 years. D recommendation.

Grade A recommendation = nekoliko studija s najvecim nivom (RCT - randomized controlled trials).

Ovo normalno ne ukljucuje ljude koji su imali cireve na zeludcima i prethodno gastrointestinalno krvarenje.

Na drugu ruku, vecina Aspirina koji se prodaje danas dolazi u EC = entericaly coated capsules. To su posebne pilule koje dodatno osiguravaju prevenciju stomacnih ulcera pri koristenju aspirina. Takodje smanjuju osjecaj zgaravice kod koristenja aspirina, sto je jedna od najcescih prigovora koje pacijenti imaju.

I na kraju, vecina cireva koji su uzrokovani NSAIDs, i sami zarastu, s nekim od proton pump inhibitor ljekova (omeprazole/pantaprazole, etc). Dok, recimo infarkti miokarda i mozdani udari nece se nikad podmladiti. Isto tako, pogledati treba gdje je krvarenje iz gastointestinalnog trakta na ljestvici po pitanju mortaliteta, a gdje su srcani i mozdani udari.

Normalno, ovo je primarna prevencija. Slicno kao i vakcinacija. Nas gro nikad nije bilo izlozeno tuberkulozi, pa bebama i dalje daju BSG vakcinu. Tako je i ovo, hit & miss. Ali, za onog ko o sebi vodi racuna, aspirin je uvijek dobra stvar. Normalno kad se koristi treba izbjegavati koristenje drugih NSAID's za bolove, vec koristiti striktno paracetamol/Tylol. Diklofenaci, Ibuprofeni, itd se nebi trebali koristiti istovremeno, u velikim dozama. Takodje i steroidi, kao prednison, se nebi trebali uzimati zajedno bez nekog ljeka koji supresira stomacnu kiselinu. I treba voditi racuna da ti stolica ne promjeni boju u crnu. Ako ti stolica pocrni to znaci da krvaris negdje, ukoliko nisi na suplementima sa zeljezom. Tako da svaki dan moze se pokazati i dokazati da li krvaris ili ne.

Vecina kronicnih srcanih bolesnika je na tkz. troduploj antikoagulacionoj terapiji - Aspirini, Plavix ili Clopidogrel, i Warfarin ili Kumarin, kad udruzis ovakva tri ljeka zajedno, to je nesto sasvim drukcije od baby aspirina svaki dan.
Sto se tice efekta Aspirina na kolorektalne rakove, ne postoje nikakve generalne preporuke, iako u zadnje vrijeme je bilo nekoliko studija koje su sve zakljucile da koristenje aspirina je umanjilo broj onih s rakom, od 16-40%. Ovo se odnosi samo na Gastrointestinalne rakove.

Uvazeni gospodine Lacrosse svaka cast na postu - zaista ste odvojili vremena, i ovakav savjet vrijedi zlata.

Dakle, razmisljam da mami pocnem da dajem po 1 aspirin dnevno, ima malko nizi krvni pritisak (110/70) i otkucaje srca normala (60-70) po minuti, ima 58 godina zivota.

Da li da joj dajem po jedan aspirin npr 75mg svaku vece pred spavanje sa casom caja - inace pije minimum 2l tecnosti dnevno (bez secera) uglavnom cajevi i jede oko 1kg voca dnevno (sada jede po 3kg lubenice minimum hehehe), nista masno, nista nezdravo, normalna kilaza.

Koristi od GNLD Omega 3 i Tre-en-en, te GNLD KalMag +d te ponekad Corokutovo ulje (svaki drugi mjesec po dozu za mjesec).

Hvala ti jos jednom, savjeti su ti odlicni !

[Lacrosse]

Za osobe koje imaju dijabetis, hipertenziju, koronarna oboljenja, hiperlipidemije (visok kolesterol), baby aspirin dnevno je esencijalna terapija.

Za sve druge je opcijalna ali se preporucuje.
Moja je mati na aspirinu, i sve zene poslje menupauze trebaju da su na vitamin D 800 IU (international units) i calicijumu.

Kako aspirin sprijecava mozdani udar?
Zene su narucito sklone aritmijama.
Najcesca aritmija na svijetu je atrijalna fibrilacija.
Atrijalna fibrilacija moze biti aritmija kratkog trajanja sa povratkom normalnog srcanog ritma i frekfence. Ali, u momentima dok je neko u atrijalnoj fibrilaciji, ugrusak ili tromb se formira u srcanoj pretkljetki. Taj isti tromb nakon sto neko nije u aritmiji ide pravu u glavu. Cesto je taj mozdani udar zapravo prvi znak koji imamo da uopste i imamo aritmiju. Zbog toga, uzimanje aspirina moze pomoci. U studijima samo uzimanje aspirina umanjuje sansu od mozdanog udara kod zena 17%. Tako da, mala doza aspirina je preporucljiva.

Asprini takodje djeluje na rakove koji se formiraju preko polypa. To su u prvom redu kolorectalni rakovi. Prema onom sto se pretpostavlja iz istrazivanja, aspirin preko celularne masinerije dovodi do apopotoze, tj. smrti kancerogene celije.

Jedini pacijenti kojima se aspirin ne preporucuje su ljudi s istorijom gastroenteroloskog krvarenja i asmaticari koji reaguju na NSAIDS, dakle ne svaki asmaticar, nego mali krug njih koji su osjetljivi, ali vecina ljudi to vec i sama zna.

[talić]

@ Lacrosse,
ja nisam internista ali mi isto tako ni jedna farmaceutska kompanija ne plaća godišnje odmore i ne uplaćuje lovu na račun negdje u Austriji, u mojoj čekaonici i mom uredu nema brda reklamnih kataloga raznoraznih preparata kao što ih viđam u posljednje vrijeme u svim ordinacijama od porodične medicine do specijalističkih klinika.
Ja ne kažem da Aspirin nije dobar ni za koga nego da treba odvagati korist i štetu i da se ne treba kljukati nepotrebnim lijekovima i preparatima.
Ako se zna da paracetamol oštećuje jetru čemu uzimanje paracetamola i kada se može izbjeći terapija.
Ako se zna da GE 132 nije dobar zašto nas liječnička komora ne zaštiti svakodnevnog bombardovanja reklamama i pojavljivanjem nekih kvazi stručnjaka.
Ne vidjeh nigdje javno istupanje liječničke komore da se bori za nas kao pacijente da nam omogući kompletne tretmane do transplatacija nego smo prinuđeni da prosjačimo za liječenje vani.
Jednostavno rečeno povjerenje više ne postoji, prošla su vremena kad su ljudi imali informacije samo o svojoj struci tako da i liječnik može provjeriti da li mu je arhitekta podvalio loš građevinski materijal kao što i ja mogu saznati da li mi je liječnik prepisao dobru terapiju.