Normalan narod koji ne pada na glupe priče o Bill Gatesu, 5G i čipovanju će primiti vakcinu da se polako riješi ovo sranje od pandemije.
mozes, ali u principu tvoje misljenje je irelevantno pogotovo u krugovima ljudi koji su potrosili dobar dio zivota ili cijeli zivot da se obrazuju,a ti samo da listas seracke sajtove žute štampe nepismenih kurvi i kretena preko istočne granice BiH, i oni su ti mjerilo poimanja zivota...grickoo wrote: ↑24/11/2020 17:53Ne smije se misljenje izraziti?agnostic_front wrote: ↑24/11/2020 17:22 Dodje covjek da sazna o razvoju vakcine, antivakseri dominiraju temom. Ocekivano doduse.
Ja neću, ako me neće čipovatiMilenkov buraz wrote: ↑25/11/2020 17:08Vjeruj ja bih je prvi primio, gdje treba stati u red?
Tradicionalna, ubacuje se oslabljeni virus koji nema mogucnost reprodukovanja. Navodno u maju ove godine sedam kompanija od njih stotinjak je razvijalo ovaj tip vakcine. Problem sa ovom tradicionalnom je da proizvodnja uzima vremena tako da cisto sumnjam da ce nas ove zapasti.I. Whole-Pathogen Vaccines
Traditional vaccines consist of entire pathogens that have been killed or weakened so that they cannot cause disease. Such whole-pathogen vaccines can elicit strong protective immune responses. Many of the vaccines in clinical use today fall into this category. However, not every disease-causing microbe can be effectively targeted with a whole-pathogen vaccine.
Druga generacija, ne ubrizgava se oslabljen virus vec samo antigen i najcesce treba dodatna vakcinacija koja pojacava imuni sistem (sta sa ljudima sa autoimunim bolestima?, da li utice). Na ovoj platformi su razvijene vakcine za veliki kasalj, hepatitis B, meningitis. Najveci broj vakcina za Covid, ca. 50% od ukupnog broja je razvijalo ovu vrstu vakcine.II. Subunit Vaccines
Instead of the entire pathogen, subunit vaccines include only the components, or antigens, that best stimulate the immune system. Although this design can make vaccines safer and easier to produce, it often requires the incorporation of adjuvants to elicit a strong protective immune response because the antigens alone are not sufficient to induce adequate long-term immunity.
Treca generacija koja ce biti po prvi put upotrijebljena. Pojednostavljeno ubacuje se genetski kod koji instruise nase tijelo da proizvodi antigene za taj virus. Navodno vakcina od americke kompanije Moderna uradjena na ovoj platformi, bila vijest juce da je EU potpisala ugovor s njima za 160 miliona doza.III. Nucleic Acid Vaccines
Another investigational approach to vaccination involves introducing genetic material encoding the antigen or antigens against which an immune response is sought. The body’s own cells then use this genetic material to produce the antigens. Potential advantages of this approach include the stimulation of broad long-term immune responses, excellent vaccine stability and relative ease of large-scale vaccine manufacture. Many such vaccines are in the research pipeline, although none are currently licensed for human use.
Vi o mnogim zenama imate poprilicno gadno misljenje. Cudan level frustracijevjeshalica wrote: ↑25/11/2020 16:56mozes, ali u principu tvoje misljenje je irelevantno pogotovo u krugovima ljudi koji su potrosili dobar dio zivota ili cijeli zivot da se obrazuju,a ti samo da listas seracke sajtove žute štampe nepismenih kurvi i kretena preko istočne granice BiH, i oni su ti mjerilo poimanja zivota...grickoo wrote: ↑24/11/2020 17:53Ne smije se misljenje izraziti?agnostic_front wrote: ↑24/11/2020 17:22 Dodje covjek da sazna o razvoju vakcine, antivakseri dominiraju temom. Ocekivano doduse.
Jel to sve sto imas da izjavis? Jedini domet? Hajde fino za tebe.grickoo wrote: ↑25/11/2020 19:19Vi o mnogim zenama imate poprilicno gadno misljenje. Cudan level frustracijevjeshalica wrote: ↑25/11/2020 16:56mozes, ali u principu tvoje misljenje je irelevantno pogotovo u krugovima ljudi koji su potrosili dobar dio zivota ili cijeli zivot da se obrazuju,a ti samo da listas seracke sajtove žute štampe nepismenih kurvi i kretena preko istočne granice BiH, i oni su ti mjerilo poimanja zivota...
Može li malo više o tome gdje si primio, kako, šta, nešto napismeno....freelancerBIH wrote: ↑25/11/2020 19:26 Lijepe vijesti iz Amerike - 20 miliona vakcinisanih ce biti u decembru 2020 - ista vakcina koju sam ja primio. Ovo su odlicne vijesti! Malo po malo idemo u kraj ovom smecu od virusa
https://www.bloomberg.com/news/articles ... -19-spread
How a Covid-19 Vaccine Could End Up Helping the Virus Spread
A vaccine that protects against symptoms of Covid-19 could contribute to the spread of the disease if—and this is still just an if—the people who get vaccinated remain capable of carrying and transmitting the virus. That’s a risk that’s gotten little attention amid the deserved jubilation over a Nov. 9 report from Pfizer Inc. and BioNTech SE that their vaccine candidate appears to be highly effective.
It’s a matter of timing. If everyone in the world is vaccinated, or has developed antibodies through exposure to the disease, there will be no problem. But in the early going, when only some people are protected, they could unwittingly spread the disease to people who are still vulnerable. The vaccinated people might stop wearing masks and social distancing since they aren’t themselves at risk anymore. They could be carrying the SARS-CoV-2 virus, even if they’re not getting sick from it.
How big a problem this might be is hard to say, because we don't know for sure if immunized people are capable of shedding infectious virus. It's possible that their antibodies will eradicate any infection pretty quickly, so they might just shed viral debris. Pfizer and the Centers for Disease Control and Prevention did not immediately respond to requests for comment.
It’s also not yet clear how much protection the Pfizer-BioNTech vaccine and others would provide. The gold standard is to achieve sterilizing immunity, which is so strong that the virus can’t get a grip in the body at all—meaning that vaccinated people are safe to others. The human papillomavirus vaccine provides sterilizing immunity, for example. But sterilizing immunity is hard to achieve with viruses such as SARS-CoV-2, which enter through the respiratory system. The only sure way to know if the vaccine provides sterilizing immunity would be to check whether trial subjects who remain free of Covid-19 have been exposed to it, by tracing their contacts.
The Pfizer-BioNTech vaccine and others might provide just functional immunity—protecting people from the full-blown disease but not from carrying the virus. Functional immunity may also be what people get from being infected by the disease itself. They can catch it again, but will have fewer, if any, symptoms. We already know that people who are asymptomatic can spread Covid-19. In fact, that’s one of its scariest characteristics.
Bloomberg’s Jason Gale raised this issue with Paul Griffin, a professor in the faculty of medicine at the University of Queensland in Australia. Griffin, who is an investigator on four Covid-19 vaccines that do not include the Pfizer-BioNTech one, said that while it might turn out that vaccinated people can transmit the disease, transmission is far more likely if people are coughing and sneezing. “So if we are preventing clinical disease, then that will go a long way to reducing transmission as well, even if it's not precisely a transmission-blocking vaccine,” Griffin said on Nov. 10.
In other words, under the right conditions, a vaccine can and should suppress the transmission of Covid-19. But if people who get vaccinated throw caution to the winds, it’s possible they could get a lot of other people sick.
https://www.thelancet.com/journals/lanc ... 0/fulltext
What can we expect from first-generation COVID-19 vaccines?
These observations suggest that we cannot assume COVID-19 vaccines, even if shown to be effective in reducing severity of disease, will reduce virus transmission to a comparable degree. The notion that COVID-19-vaccine-induced population immunity will allow a return to pre-COVID-19 “normalcy” might be based on illusory assumptions.
Hvala za objasnjenje. Absolutno nije preopsirno, pogotovo za nekog ko nikad nije nista zavrsio u jednoj recenici.Mogy87 wrote: ↑25/11/2020 21:01 @Grean vakcina koju su razvili Pfizer/BioNtech i Moderna se zasniva na mRNA tehnologiji. Po ovoj tvojoj podjeli spada u Nucleic Acid Vaccines. Ta tehnologija do sada nije koristena za "konvencionalne" vakcine, ali se itekako primjenjuje za imunoterapiju koja je revolucija u lijecenju karcinoma. Za oboljele od kancera prave se personalizirane "vakcine" koje omogucuju organizmu da celije raka prepozna kao "neprijateljske" i izbori se s njima (najjednostavnije objasnjeno).
We are also applying our mRNA technology to the emerging field of immuno-oncology, also often referred to as immunotherapy. This therapeutic area involves harnessing the body’s immune system to identify and kill cancer cells in the same way the immune system identifies and targets infection from pathogens.
Sa stranice Moderne:
https://www.modernatx.com/pipeline/ther ... o-oncology
BioNtech (Pfizerov partner) nudi slicne proizvode:
https://biontech.de/how-we-translate/biontech-approach
AstraZeneca/Oxford i Johnson&Johnson su vakcine koje koriste viralni vektor
Ove vakcine pomoću genetički modifikovanih adenovirusa (koji su bezopasni) u organizam ubacuju dio virusa SARS-CoV-2 koji izaziva imunološku reakciju. Tu je adenovirus neka vrsta transportnog sredstva. Spadaju u rekombinantne vakcine (nisu navedene na tvojoj listi) i takodjer su treca generacija.
Ova tehnologija je takodjer dosta nova, ali su je naucnici sa Oxforda koristili prilikom istrazivanja za vakcine protiv SARSa1 i MERSA (koje na kraju nisu bile potrebne) tako da je bolje poznaju.
Ako te zanima zasto ove "starije" metode proizvodnje vakcina nisu bile moguce vise informacija mozes dobiti na ovom linku uz napomenu da je clanak pisan na pocetku pandemije i ne ukljucuje otkrica do kojih su naucnici dosli vec samo eventualne razloge zasto neka od tehnika ne bi bila odgovarajuca.
https://imunizacija.hr/novi-virus-novo-cjepivo/
Nadam se da nisam bila previse opsirna i da sam ti uspjela koliko toliko pokasniti stvari. Ako imas jos koje pitanje slobodno pitaj.
I druga strana priče:daddy-kool wrote: ↑25/11/2020 23:22https://www.bloomberg.com/news/articles ... -19-spread
How a Covid-19 Vaccine Could End Up Helping the Virus Spread
A vaccine that protects against symptoms of Covid-19 could contribute to the spread of the disease if—and this is still just an if—the people who get vaccinated remain capable of carrying and transmitting the virus. That’s a risk that’s gotten little attention amid the deserved jubilation over a Nov. 9 report from Pfizer Inc. and BioNTech SE that their vaccine candidate appears to be highly effective.
It’s a matter of timing. If everyone in the world is vaccinated, or has developed antibodies through exposure to the disease, there will be no problem. But in the early going, when only some people are protected, they could unwittingly spread the disease to people who are still vulnerable. The vaccinated people might stop wearing masks and social distancing since they aren’t themselves at risk anymore. They could be carrying the SARS-CoV-2 virus, even if they’re not getting sick from it.
How big a problem this might be is hard to say, because we don't know for sure if immunized people are capable of shedding infectious virus. It's possible that their antibodies will eradicate any infection pretty quickly, so they might just shed viral debris. Pfizer and the Centers for Disease Control and Prevention did not immediately respond to requests for comment.
It’s also not yet clear how much protection the Pfizer-BioNTech vaccine and others would provide. The gold standard is to achieve sterilizing immunity, which is so strong that the virus can’t get a grip in the body at all—meaning that vaccinated people are safe to others. The human papillomavirus vaccine provides sterilizing immunity, for example. But sterilizing immunity is hard to achieve with viruses such as SARS-CoV-2, which enter through the respiratory system. The only sure way to know if the vaccine provides sterilizing immunity would be to check whether trial subjects who remain free of Covid-19 have been exposed to it, by tracing their contacts.
The Pfizer-BioNTech vaccine and others might provide just functional immunity—protecting people from the full-blown disease but not from carrying the virus. Functional immunity may also be what people get from being infected by the disease itself. They can catch it again, but will have fewer, if any, symptoms. We already know that people who are asymptomatic can spread Covid-19. In fact, that’s one of its scariest characteristics.
Bloomberg’s Jason Gale raised this issue with Paul Griffin, a professor in the faculty of medicine at the University of Queensland in Australia. Griffin, who is an investigator on four Covid-19 vaccines that do not include the Pfizer-BioNTech one, said that while it might turn out that vaccinated people can transmit the disease, transmission is far more likely if people are coughing and sneezing. “So if we are preventing clinical disease, then that will go a long way to reducing transmission as well, even if it's not precisely a transmission-blocking vaccine,” Griffin said on Nov. 10.
In other words, under the right conditions, a vaccine can and should suppress the transmission of Covid-19. But if people who get vaccinated throw caution to the winds, it’s possible they could get a lot of other people sick.https://www.thelancet.com/journals/lanc ... 0/fulltext
What can we expect from first-generation COVID-19 vaccines?
These observations suggest that we cannot assume COVID-19 vaccines, even if shown to be effective in reducing severity of disease, will reduce virus transmission to a comparable degree. The notion that COVID-19-vaccine-induced population immunity will allow a return to pre-COVID-19 “normalcy” might be based on illusory assumptions.
No successful and effective vaccine has ever been developed against any previous coronavirus!
There is absolutely no need for vaccines to shut down the pandemic because the pandemic is actually over. Don't vaccinate people who are not in danger of illness. Also don't plan on vaccinating millions of healthy people with vaccines that aren't extensively tested on people. The instinct for universal vaccine has a ′′ breath of evil ′′ that I will ′′ vigorously oppose ". A very small number of people in the world will need a vaccine against Covid-19 because the death rate is low, and the disease obviously does not cause excess mortality.
Ja se iskreno nadam da si u pravu. I da ne dijelim planetu s osobom koja kaze da 200K dodatno umrlih nije rast na koji se treba obazirati.
Mogy87 wrote: ↑26/11/2020 10:38Ja se iskreno nadam da si u pravu. I da ne dijelim planetu s osobom koja kaze da 200K dodatno umrlih nije rast na koji se treba obazirati.