Corona cjepivo/vakcina - News
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#876 Re: Corona cjepivo/vakcina - News
Dok god politika diktira koja i kada ce vakcina biti izbacena nema tu hajra. Do sada se medicina mijesala u politicke odluke a ovi ih zauzvrat pozuruju sa vakcinom. Nema izlaza dok se presjek ne napravi i donese politicka odluka da se sve mjere ukinu a medicini kaze da se posveti svojim istrazivanjima bez medijskih istupa. Do sada najbrze napravljena vakcina je ona protiv zausnjaka 4 godine. Ovu hoce da sklepaju za 6 mjeseci. Jedini koji je to prokljuvio je trump.
- zubi
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#877 Re: Corona cjepivo/vakcina - News
grickoo wrote: ↑26/11/2020 19:53 Dok god politika diktira koja i kada ce vakcina biti izbacena nema tu hajra. Do sada se medicina mijesala u politicke odluke a ovi ih zauzvrat pozuruju sa vakcinom. Nema izlaza dok se presjek ne napravi i donese politicka odluka da se sve mjere ukinu a medicini kaze da se posveti svojim istrazivanjima bez medijskih istupa. Do sada najbrze napravljena vakcina je ona protiv zausnjaka 4 godine. Ovu hoce da sklepaju za 6 mjeseci. Jedini koji je to prokljuvio je trump.
Jazuk, tako promucuran a odeee
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#878 Re: Corona cjepivo/vakcina - News
Jazuk ce bit kad nastampaju 2 milijarde vakcina a ne bude dobrovoljaca.zubi wrote: ↑26/11/2020 19:54grickoo wrote: ↑26/11/2020 19:53 Dok god politika diktira koja i kada ce vakcina biti izbacena nema tu hajra. Do sada se medicina mijesala u politicke odluke a ovi ih zauzvrat pozuruju sa vakcinom. Nema izlaza dok se presjek ne napravi i donese politicka odluka da se sve mjere ukinu a medicini kaze da se posveti svojim istrazivanjima bez medijskih istupa. Do sada najbrze napravljena vakcina je ona protiv zausnjaka 4 godine. Ovu hoce da sklepaju za 6 mjeseci. Jedini koji je to prokljuvio je trump.
Jazuk, tako promucuran a odeee
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#880 Re: Corona cjepivo/vakcina - News
Ja razumijem da je cijenjenom gospodinu politicaru koji je prvo bio na hrvatskom pa se onda prebacio na budzet EU nepojmljivo da naucnici nemaju bas vremena hodati po simpozijima...jer eto desila se najveca zdravstvena kriza u posljednjih par desetljeca. Pa eto naucnici prionuli na posao, nemaju kad sazivati simpozije.
A neka se ne brine, dijele oni znanja izmedju sebe. Samo ne s jeftinim populistima.
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#881 Re: Corona cjepivo/vakcina - News
Potpuno pogresno rezonujes.
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#882 Re: Corona cjepivo/vakcina - News
Treba birokrata koji gradi politicku karijeru da mi otvara oci
Covjek koji kritikuje informaticara da se mijesa u medicinske teme, a ima obraza da tvrdi da je COVID obicna prehlada, a po profesiji je pravnik. Nije licemjerno sekunde.
Covjek koji kritikuje informaticara da se mijesa u medicinske teme, a ima obraza da tvrdi da je COVID obicna prehlada, a po profesiji je pravnik. Nije licemjerno sekunde.
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#883 Re: Corona cjepivo/vakcina - News
Ne nego geek koji ne moze antivirus za worpad da napravi treba da ti otvara oci na globalnom nivou.
Ili na regionalnom djikic ... wanabe naucnik koji eto ima vremena svakodnevno da daje intervjue i namece se iako ga niko nista ne pita. Lik koji prati brojke koje mediji lupaju i pricu okrece prema njima.
Ili na regionalnom djikic ... wanabe naucnik koji eto ima vremena svakodnevno da daje intervjue i namece se iako ga niko nista ne pita. Lik koji prati brojke koje mediji lupaju i pricu okrece prema njima.
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#886 Re: Corona cjepivo/vakcina - News
Evo dacu ti i ovu rusko englesku kombinaciju.
- Edin H.
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#888 Re: Corona cjepivo/vakcina - News
To je vec teoretisanje. Evo nek englezi pristanu pa nek vide sta to rusi imeju. Ako je smece ko sto kazes cijeli zapad ce to jedva docekati zar ne?
- Lao Ce
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#890 Re: Corona cjepivo/vakcina - News
Koliko sam shvatio maske će i dalje morati biti obavezne, Gdje je to onda vraćanje u normalu? Možda vraćanje u novo normalnoBlackRiver wrote: ↑26/11/2020 13:40 Ljudi i dalje vjeruju kako ce vakcina nesto promijeniti i kako cemo se vratiti u normalu.
Simpaticno, nema sta
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#892 Re: Corona cjepivo/vakcina - News
Zakljuci ljekara koji se bavi klinickim istrazivanjima. Uz cinjenicu da su razvijene vakcine imale odlicnu bazu zasnovanu na saznanjima koja su naucnici stekli prilikom istrazivanja za vakcinu za MERS i SARS 1.
Less than a year to develop a COVID vaccine – here’s why you shouldn’t be alarmed
I’m a clinical trials geek. I keep hearing people talk about the seven to ten years it takes to make a vaccine and how dangerous speeding this up might be. The word that keeps popping up is “rushed”, and it is making the average person nervous about vaccine safety. So, as a clinical trials doctor, I am going to tell you what I do for most of those ten years – and it is not very much.
I’m not lazy. I submit grants, have them rejected, resubmit them, wait for review, resubmit them somewhere else, sometimes in a loop of doom. When I am lucky enough to get trials funded, I then spend months on submitting to ethics boards. I wait for regulators, deal with personnel changes at the drugs company and a “change of focus” away from my trials, and eventually, if I am very lucky, I spend time setting up trials: finding sites, training sites, panicking because recruitment is poor, finding more sites. I then usually have more regulatory issues and, finally, if my big pot of luck is not used up, I might have a viable therapy – or not.
At this point, it might get delayed because of questions over profitability or any number of other obstacles. I’m not even going to go into the years it normally takes to get the “preclinical” studies, the ones before the human trials, done.
Ten years to develop a vaccine is a bad thing
So next time somebody expresses concern at the astonishing speed the vaccine trials have happened at, point out to them that ten years isn’t a good thing, it’s a bad thing. It’s not ten years because that is safe, it’s ten hard years of battling indifference, commercial imperatives, luck and red tape. It represents barriers in the process that we have now proved are “easy” to overcome. You just need unlimited cash, some clever and highly motivated people, all the world’s trial infrastructure, an almost unlimited pool of altruistic, wonderful trial volunteers and some sensible regulators.
With all of this and the clock ticking on a global pandemic killing people by the second, it turns out we can do amazing things. The vaccine trials have been nothing short of a miracle. A revolution in how we do trials that when you think about it is perhaps not that surprising given our ability to innovate when we really need to.
And we really need to – necessity being the mother of invention. Safety has not been compromised. All trials have been through the correct “phases” or process of any normal drug or vaccine. Hundreds of thousands of the very best of us volunteered and had an experimental vaccine. The world watched so closely that when a single person fell ill, we were all debating it.
To date, there has not been a single associated death related to COVID vaccines and only a handful of potentially serious events. Just imagine watching everybody in a small city for six months and reporting every single heart attack, stroke, neurological condition or anything that might be judged serious. How astonishing is this? It has been a triumph of medical science.
I haven’t even touched on the lucky confluence of timing that meant this all happened at a time when sequencing all the genes in a person or virus is so routine nobody bats an eyelid. This turbocharged the early preclinical science needed as the foundation stone of several new technologies at the right point to be exploited.
At this time, three vaccines have already broken cover and demonstrated efficacy higher than we had ever hoped. The bar was set by regulators at around 50%. Both Moderna and Pfizer reported 95% efficacy, and Oxford University reported 90% efficacy for a particular dosage regimen. Safety data is still to follow, but the track record of vaccines is excellent, and I am an optimist.
None of this is to downplay the challenges still ahead. It is also not to say vaccines are without safety questions still to be answered. It has been, however, a triumph of good process and great people. I am confident that when regulators pore over the safety and efficacy data, closely followed by every interested scientist in the world, that vaccines will only be used if their benefits clearly outweigh the risks – and you should be confident too.
https://theconversation.com/less-than-a ... KbybxLikXA
Less than a year to develop a COVID vaccine – here’s why you shouldn’t be alarmed
I’m a clinical trials geek. I keep hearing people talk about the seven to ten years it takes to make a vaccine and how dangerous speeding this up might be. The word that keeps popping up is “rushed”, and it is making the average person nervous about vaccine safety. So, as a clinical trials doctor, I am going to tell you what I do for most of those ten years – and it is not very much.
I’m not lazy. I submit grants, have them rejected, resubmit them, wait for review, resubmit them somewhere else, sometimes in a loop of doom. When I am lucky enough to get trials funded, I then spend months on submitting to ethics boards. I wait for regulators, deal with personnel changes at the drugs company and a “change of focus” away from my trials, and eventually, if I am very lucky, I spend time setting up trials: finding sites, training sites, panicking because recruitment is poor, finding more sites. I then usually have more regulatory issues and, finally, if my big pot of luck is not used up, I might have a viable therapy – or not.
At this point, it might get delayed because of questions over profitability or any number of other obstacles. I’m not even going to go into the years it normally takes to get the “preclinical” studies, the ones before the human trials, done.
Ten years to develop a vaccine is a bad thing
So next time somebody expresses concern at the astonishing speed the vaccine trials have happened at, point out to them that ten years isn’t a good thing, it’s a bad thing. It’s not ten years because that is safe, it’s ten hard years of battling indifference, commercial imperatives, luck and red tape. It represents barriers in the process that we have now proved are “easy” to overcome. You just need unlimited cash, some clever and highly motivated people, all the world’s trial infrastructure, an almost unlimited pool of altruistic, wonderful trial volunteers and some sensible regulators.
With all of this and the clock ticking on a global pandemic killing people by the second, it turns out we can do amazing things. The vaccine trials have been nothing short of a miracle. A revolution in how we do trials that when you think about it is perhaps not that surprising given our ability to innovate when we really need to.
And we really need to – necessity being the mother of invention. Safety has not been compromised. All trials have been through the correct “phases” or process of any normal drug or vaccine. Hundreds of thousands of the very best of us volunteered and had an experimental vaccine. The world watched so closely that when a single person fell ill, we were all debating it.
To date, there has not been a single associated death related to COVID vaccines and only a handful of potentially serious events. Just imagine watching everybody in a small city for six months and reporting every single heart attack, stroke, neurological condition or anything that might be judged serious. How astonishing is this? It has been a triumph of medical science.
I haven’t even touched on the lucky confluence of timing that meant this all happened at a time when sequencing all the genes in a person or virus is so routine nobody bats an eyelid. This turbocharged the early preclinical science needed as the foundation stone of several new technologies at the right point to be exploited.
At this time, three vaccines have already broken cover and demonstrated efficacy higher than we had ever hoped. The bar was set by regulators at around 50%. Both Moderna and Pfizer reported 95% efficacy, and Oxford University reported 90% efficacy for a particular dosage regimen. Safety data is still to follow, but the track record of vaccines is excellent, and I am an optimist.
None of this is to downplay the challenges still ahead. It is also not to say vaccines are without safety questions still to be answered. It has been, however, a triumph of good process and great people. I am confident that when regulators pore over the safety and efficacy data, closely followed by every interested scientist in the world, that vaccines will only be used if their benefits clearly outweigh the risks – and you should be confident too.
https://theconversation.com/less-than-a ... KbybxLikXA
- _BataZiv_0809
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#893 Re: Corona cjepivo/vakcina - News
@Mogy87 hoce li ovo usporiti Oxford vakcinu? Kad se predaje za dozvolu?
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#894 Re: Corona cjepivo/vakcina - News
Dva su paralelna sistema odobravanja (sad i treci radi Brexita)._BataZiv_0809 wrote: ↑27/11/2020 08:50 @Mogy87 hoce li ovo usporiti Oxford vakcinu? Kad se predaje za dozvolu?
U EU rolling review je poceo jos u oktobru kad su poslali prve podatke EMA. Salje se malo po malo podataka kako pristizu iz klinickih ispitivanja.
U UK takodjer je zapocet proces odobravanja neovisno od EU odobrenja.
E sad najveca prepreka je FDA odnosno odobrenje u SAD jer oni traze pune podatke. Plus vrlo vjerovatno nece prihvatiti podatke iz istrazivanja iz drugih drzava, a ova promjena protokola (pola doze, cijela doza) se desila van SAD. I sad umjesto da organizuju dodatna ispitivanja efikasnosti u USA vjerovatno ce napraviti jos jedan krug medjunarodnog ispitivanja. S obzirom da znaju da je efikasnost velika vjerovatno ce im trebati manji broj ucesnika i sve ce ici brze.
Za nas je puno vaznija EMA i od njihove dozvole sve zavisi. Ova frtutma se vise odnosi na USA, ali vidjet cemo sta ce evropski regulator reci.
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#895 Re: Corona cjepivo/vakcina - News
Hvala
Drzimo fige
Drzimo fige
- GAU8
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#897 Re: Corona cjepivo/vakcina - News
Dakle, kraj februara.
- drag_gost
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#898 Re: Corona cjepivo/vakcina - News
Jos bitnije: hoce li pacijent potpisati da ce snositi odgovornost ako nekoga zarazi? Ovo gore iznad je jako, jako sebicno.
- GAU8
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#899 Re: Corona cjepivo/vakcina - News
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#900 Re: Corona cjepivo/vakcina - News
Ja bih ovo malo popravio:
Hoce li pacijent potpisati da se nece lijeciti u domu zdravlja ako se razboli od bolesti za koju je odbio primiti vakcinu